NFL 2022 Season

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Here's a factoid I enjoyed:

Matt Ryan and Russell Wilson began and spent most of their careers on NFC bird teams. This offseason, both got traded to AFC horse teams
 
Gotta be brutal to be a Bronco's fan right now. Seeing a lot of talk online from fans in despair knowing their team is crippled by the whole Russ deal. It's honestly playing out a lot like I felt it would after watching Russ the last few years. I just didn't realize how much of his actual success was because of Pete playing to his strengths and him having Lynch, Lockett, Baldwin and others along the way who bailed him out. When Russ is left to his own devices, which is what he demanded of a team that took him on, the guy is a complete disaster. His hubris is the cause for all of this so far, and I'm not sure he has it in him to humble himself and fix it.
 
I think his MVP campaign dreams are over for this year, so on to comeback player of the year for 2023 I guess...

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His hubris is the cause for all of this so far, and I'm not sure he has it in him to humble himself and fix it.
May not be his choice, meaning the more damaged the brain the less likely insight connects to executive function, memory centers, or even premotor regions. Confidence and hubris is not lacking in most football players. Years ago the Seahawks draft also included cognitive performance. If you want a top team, you probably shouldn't restrict cognitive testing to draftees, particularly if you are seeing year over year declines. If you did, wouldn't you encourage them to leave your team? If the NFL wanted to be transparent about the cost of the game and how to protect the kids and adults who play, cognitive performance testing defines two groups, one that stays well, one that doesn't. Next step, the compare and contrast genetically and exposure wise as to why the scores decline. Then aim to modify the nature and nurture that adversely impacts the players....They have a well funded platform to study this that could apply to all kinds of brain trauma, the burdens of which are enormous within our communities and world wide.

This next part is more serious, and an example of what we know re brain trauma. In the epilepsy world there are people who get seizures after brain injury. There are people who have the exact same brain injury and don't ever get epilepsy. When you work backwards the group that got seizures are way more likely to have a defect in a gene with the worst/best acronym in medicine MTHFR. There are other genes they may also have in common, but that MTHFR gene has a workaround whereas most genes have no therapy for them when they don't work. MTHFR helps methylate B-group vitamins B12 and Folate. That methylation of those vitamins enables cell division and repair strategies. Specifically protein production and DNA production. Many of us have one copy that's weird and about 1/9 have two copies that are weird. So it is a really common gene variant to be less efficient at what it helps do. Most of the time that inefficiency doesn't matter, at least until you have dangerous injury or time of stress (pregnancy, sepsis, brain injury, stroke). The reason it is super fascinating is there are methylated versions of B12 and Folate that are cheap and easily available that bypass what the MTHFR gene was supposed to do. The notion that a safe straightforward and cheap methylated version of B12 and Folate might be important in diminishing burdens of brain injury remains to studied in a good prospective trial.

Given side effects of B12 and Folate low dose are virtually zero, and they are water soluble vitamins you pee out any excess of, If I was a football player, or had brain traumas with any regularity, I would be popping low dose Methyl B12 and Methylfolate every day.
 
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Or.....don't look for work that entails head trauma on a daily basis.
 
May not be his choice, meaning the more damaged the brain the less likely insight connects to executive function, memory centers, or even premotor regions. Confidence and hubris is not lacking in most football players. Years ago the Seahawks draft also included cognitive performance. If you want a top team, you probably shouldn't restrict cognitive testing to draftees, particularly if you are seeing year over year declines. If you did, wouldn't you encourage them to leave your team? If the NFL wanted to be transparent about the cost of the game and how to protect the kids and adults who play, cognitive performance testing defines two groups, one that stays well, one that doesn't. Next step, the compare and contrast genetically and exposure wise as to why the scores decline. Then aim to modify the nature and nurture that adversely impacts the players....They have a well funded platform to study this that could apply to all kinds of brain trauma, the burdens of which are enormous within our communities and world wide.

This next part is more serious, and an example of what we know re brain trauma. In the epilepsy world there are people who get seizures after brain injury. There are people who have the exact same brain injury and don't ever get epilepsy. When you work backwards the group that got seizures are way more likely to have a defect in a gene with the worst/best acronym in medicine MTHFR. There are other genes they may also have in common, but that MTHFR gene has a workaround whereas most genes have no therapy for them when they don't work. MTHFR helps methylate B-group vitamins B12 and Folate. That methylation of those vitamins enables cell division and repair strategies. Specifically protein production and DNA production. Many of us have one copy that's weird and about 1/9 have two copies that are weird. So it is a really common gene variant to be less efficient at what it helps do. Most of the time that inefficiency doesn't matter, at least until you have dangerous injury or time of stress (pregnancy, sepsis, brain injury, stroke). The reason it is super fascinating is there are methylated versions of B12 and Folate that are cheap and easily available that bypass what the MTHFR gene was supposed to do. The notion that a safe straightforward and cheap methylated version of B12 and Folate might be important in diminishing burdens of brain injury remains to studied in a good prospective trial.

Given side effects of B12 and Folate low dose are virtually zero, and they are water soluble vitamins you pee out any excess of, If I was a football player, or had brain traumas with any regularity, I would be popping low dose Methyl B12 and Methylfolate every day.
I'll let @Cabezon jump in first before I add much .. (I can't add a thing). I played all sports early, but in the late 70's on my very bright Mom said no tackle football. I was teased all through school ..I was harassed in our football crazed school and town. My senior year the football team lost 7-0 in the KingBowl. Fishing for salmon was my fall sport! Great stuff @Wadin' Boot
 
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So many smiles from page 49 alone. he he he he he. LETS RIDE bwah ha ha ha ha. Happy Friday folks!
 
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Or.....don't look for work that entails head trauma on a daily basis.
First, fascinating information from @Wadin' Boot . I will need to read more about that protein. At some point in the near future, your GP will take a blood sample for a whole-genome sequencing and analysis. This analysis will highlight your individual risks for specific medical conditions, such as breast cancer, Alzheimers, diabetes, etc. due to the genes that you inherited. Lacking specific alleles for these disorders does not mean that you cannot acquire mutations to genes during your life to finally have these conditions, but if you inherited a mutated gene or two, you are more likely to accumulate mutations that will triggers these conditions.
But people make the same choice as in the Greek legend of Achilles all the time, not just in sports. "Achilles: β€œMy mother Thetis tells me that there are two ways in which I may meet my end. If I stay here and fight, I shall not return alive but my name will live for ever: whereas if I go home my name will die, but it will be long ere death shall take me.” (The Iliad, Book IX)". Fame is one driver, but another is an exchange their health for cash. How many 40+ year old loggers or carpenters or fishermen do you encounter, especially those that can walk/swing their arms normally? They are attracted to these well-paid, but life-shortening jobs (if not early death, decline in quality of life certainly) out of high school. Their sisters are going to college (and will make on average $630,000 [and about $900,000 for their brothers who go to college.] more than those to just have a high school diploma...).
Think about it. How does OSHA allow a business to operate in which life-threatening/ life-changing injuries are just treated as cost of doing business. After taking some financial hits for injuries from concussions (see NFL settlement) in recent years, a number of sports have put in rules (targeting, changes to the kickoff, concussion protocols) that have attempted to reduce (but not totally eliminate) some of the spectacular physical hits that make the highlight shows. [There is NO WAY Tua Tagovailoa should have been allowed back on the field after his first %*&$ concussion against Buffalo. The "independent" doctor blew it big time. But the short-term interests of the player (the Achilles syndrome) and the teams ("just win baby") coincide in a way that is detrimental to long-term health of the player.] And there are a number of fans (and old school former players / commentators) that aren't happy with these changes ("touch football") - the bread and circus types, in my opinion. These violent collisions may lead to immediate acute injury (denying the team of that player's talent for multiple games) and/or chronic injuries that shorten a player's career and their quality of life afterward. The rise of other sports (MMA....) appear to have gone in the other direction.
Steve
 
Gladiators. It's about entertainment and money. Player health is an afterthought at most. Is there any functional difference between a professional football stadium and the Colosseum?
Well, gladiators were typically slaves. These guys WANT to be there and worked their whole lives for it. They can walk out at any time.

Granted, like anything, there's nuance to that, but that's the big picture jist of it.
 
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