The data on resveratrol is really interesting. It was the hot area of aging and antioxidant research 15 years ago. Our lab focused on aging, oxidative damage, and antioxidant strategies in skeletal muscle. Resveratrol had a lot of promise and showed a lot of possible benefits, but as more studies on its in vivo intracellular effects came out, most research on it faded away as the cell culture benefits disappeared when applied in vivo. Our lab did a lot of work on it, astaxanthine, and other antioxidants. The biggest hurdle is that it is a non-specific free radical scavenger and it turns out that free radicals drive increases in reactive oxygen species and nitric oxide species that are important signaling molecules for positive adaptive response. Therefore, resveratrol suppressed the signalling responsible for positive gene expression changes. As with most things in life, when it comes to free radicals in your body: none is bad, a little is good, a lot is bad.Feels like no garden thread would be complete without mentioning invasive Japanese knotweed (https://www.nwcb.wa.gov/weeds/japanese-knotweed). I have a little bit on my property and have been fighting it for years, mostly because my next door neighbor sucks at taking care of their property.
Maybe everyone knows this already, but for me at least I was really surprised to hear it is a) edible (https://www.phillyorchards.org/2020/04/22/japanese-knotweed-edible-medicinal-invasive/#:~:text=Mature shoots are much tougher,the trend for foraged foods.) and b) super medicinal, in that it is crazy high in resveratrol - a potent antioxidant found in the skin of red grapes, and, as it turns out, found in super high concentrations in knotweed.
Here is just one of many studies on resveratrol (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435979/).
Another weird cool fact about resveratrol - studies are showing that consumption can help reduce the probability of sunburn. As a lifetime surfer, getting some sunscreen “from the inside out” would be great. Given that resveratrol is also found in red grape skins….glass of red wine, anyone?
Still don’t want knotweed in my yard, but at least now I yank it out with a respectful nod.
Also, say hello to my new supplement. I have a surf trip coming up later this month….will I come back looking more like George Hamilton? Who knows?
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I'm still hopeful it can show positive effects, supplements that are beneficial, safe, and have no side effects are quite rare.










