Not so much fishing related, but once I got started I could not stop. Made this trip to Dawson City for Dust to Dawson on a motorcycle, twice. Here are my definite stops. For a trip make a loop using the Stewart/Cassiar one direction and the John Hart coming back.
There are two road routes to the Yukon. From Anacortes the most direct route takes you to Hope, through Williams Lake, then Prince George. If you plan on driving the Alcan you will follow highway 97. John Hart Highway, to Dawson Creek (the start of the Alcan). If you choose this route, definitely detour through Hudson's Hope for the views and bridge to Ft. St. John.
Muncho Lake is a spectacular blue. Stop at Double G Services. Fresh baked bread and really good food (with an attitude)
Another must stop on this route is Liard Hot Springs. Really nice campground and super soak:
The Rancheria River is colored an odd brown/tan.
The other route heads West from Prince George on the Yellowhead Highway to Smithers. On this route you will pass some excellent steelhead rivers; Skeena, Bulkley. It may be difficult to get licenses to fish. Smithers has a great brew pub:
https://smithersbrewing.com/
Make sure to explore the Gitwanga Totem Poles. You then head North on the Stewart/Cassiar Highway. Petrol stations are rather limited so gas up.
A great detour is at Maziadan Junction, to Stewart/Hyder.
Stop at the Blue Bus for really good Fish and Chips.
there is also a Bear Walk and if you are adventurous you could drive up onto the Salmon Glacier. Dease Lake is where you will gas up. They do have a fishing derby around that time frame for Lake Trout. Got pretty close to a Grizzly at a campground just outside Dease Lake. GAS Up.
Boya Lake is another spectacular blue lake with campground before you hit the Yukon.
Both routes end up at Watson Lake and the Signpost Forest.
At Whitehorse stop at the Klondike for dinner.
https://www.klondikerib.com/