Usually for me, the sea legs tango happens after a day of sea state 5-6.. and I've been fishing from the bow taking the brunt of it while on the hook. One of these times I'm gonna see if it helps me learn Caporiea, the brazillian dance fighting art. 
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I used the scop patch for an ocean trip over the weekend. First time after using Dramamine in the past and fighting through the associated drowsiness. I put the patch on about 24 hours prior. The only side effect was dry mouth and generally feeling thirsty. I drank about 80 oz of water on the boat and more when we got back to land. I actually felt hungry on the ocean, which is rare for me. Not a hint of nausea, but then it was a mild day out there.