My wife and I fished Belize a few years ago. We stayed at a regular resort near San Pedro on Ambergris Caye and fished with Wil Flack, the owner Tres Pescados Fly Shop. It was the best of both worlds for us. Wil would pick us up in the morning at the resort's dock, we would fish most of the day, and then return to the resort in the afternoon. After fishing we could hang by the pool, snorkel, take a bike ride, or hit a bar and eat at local restaurants in San Pedro.
I need to add that Wil is a very good guide and very knowledgeable, but he could be a little intense at times when we didn't deliver a perfect cast to a tailing permit at 60 feet backhand in a 20mph wind.... But we made enough shots to catch fish and have some good times....